Osbourne, daughter of rocker Ozzy Osbourne and co-host of “Fashion Police” on E!, will replace “Gossip Girl” star Taylor Momsen as spokesperson for the line, designed by Madonna and her 14-year-old daughter Lourdes Ciccone Leon.

"Material Girl is thrilled to confirm that Kelly Osbourne is the new face for 2011,” a representative for Material Girl said in a statement. “We will be sharing all the details on this exciting new campaign in the upcoming weeks.”